Ocular Drug Distribution After Topical Administration: Population Pharmacokinetic Model in Rabbits
نویسندگان
چکیده
منابع مشابه
A pharmacokinetic model for ocular drug delivery.
A pharmacokinetic model of ocular drug delivery has been developed for describing the elimination and distribution of ocular drugs in the eye. The model, based on Fick's second law of diffusion, assumes a modified cylindrical eye with three pathways for drug transport across the surface of the eye: the anterior aqueous chamber, the posterior aqueous chamber and the retina/choroids/scleral membr...
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The aim of this study was to increase bioavailability of the antiviral drug acyclovir (ACV) when administered by the ocular route. For this purpose, a new lipophilic derivative of acyclovir was synthesized, both possessing greater lipophilicity and providing the formation of a homogeneous water dispersion with higher amount of ACV than the aqueous solution of the parent drug. This was done by c...
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OBJECTIVES We developed a population model that describes the ocular penetration and pharmacokinetics of penciclovir in human aqueous humour and plasma after oral administration of famciclovir. METHODS Fifty-three patients undergoing cataract surgery received a single oral dose of 500 mg of famciclovir prior to surgery. Concentrations of penciclovir in both plasma and aqueous humour were meas...
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ژورنال
عنوان ژورنال: European Journal of Drug Metabolism and Pharmacokinetics
سال: 2016
ISSN: 0378-7966,2107-0180
DOI: 10.1007/s13318-016-0319-4